Evidence-Based Holistic Dog Nutrition Topics — 2026-07-12
15 Q&A pairs ingested into Pinecone (dog-knowledge-database), covering 11 topics with evidence-tier tags per [[PINECONE_PROTOCOL]]. Source file: common-sense-dog-ai/scripts/qa-evidence-topics-2026-07-12.json.
Topics & evidence tiers
| Topic | Use | Tier |
|---|---|---|
| Omega-3 (EPA/DHA) | Osteoarthritis | 🟢 Strong |
| MCT oil diet | Cognitive dysfunction (senior dogs) | 🟢 Strong |
| Antioxidant-enriched diet | Brain aging | 🟢 Strong |
| Probiotics | GI disease, atopic dermatitis | 🟡 Moderate |
| CBD | OA pain, epilepsy (adjunct) | 🟡 Moderate |
| Turmeric/curcumin | Inflammation, OA | 🟠 Emerging |
| Green-lipped mussel | OA (esp. in combos) | 🟡 Low-moderate |
| Raw/fresh diets | Metabolic health | 🟠 Emerging, short-term only |
| B. longum probiotic | Anxiety | 🟠 Early/signal-only, not yet peer-reviewed |
| Acupuncture | Chronic pain (adjunct) | 🟠 Weak-mixed |
| Coriolus versicolor (PSP) | Hemangiosarcoma | 🟠🔴 Mixed — pilot promising, larger RCT found no benefit (and reduced survival in females) |
Verification notes
Per protocol step 2, I web-verified the two health-critical claims directly (rather than trusting Kyle's source doc blindly):
- Coriolus/PSP hemangiosarcoma: confirmed both the Penn Vet pilot (Brown et al., 2012, PMID 22988473) and the larger disconfirming RCT (Gedney et al., 2022, Vet & Comparative Oncology, PMID 35442554) are real and accurately characterized — including the nuance that female dogs on PSP-alone had worse survival than doxorubicin/placebo.
- CBD epilepsy RCT: confirmed the 26-dog JAVMA trial (PMID 31067185) — 33% seizure reduction vs. placebo, but responder-rate not significantly different between groups — and the follow-up 39-dog crossover (Rozental et al., 2023, JVIM) at a higher dose.
The remaining citations (Roush/JAVMA omega-3, Milgram antioxidant-brain-aging series, MCT/CDS multicenter RCT, GLM trials, probiotics/dermatitis trials, Helsinki raw-diet study, acupuncture reviews) are well-established, frequently-cited veterinary literature consistent with prior packs already in Pinecone ([[Joint Health Research]]) — not independently re-verified this round given time, but flagged here for anyone auditing.
Notable framing decisions
- Coriolus/PSP is deliberately kept in the knowledge base as a cautionary example — the assistant should cite it when a user asks about "natural cancer cures" to illustrate that an encouraging pilot doesn't guarantee benefit in a larger trial, and to reinforce that supplements don't replace standard oncologic care.
- B. longum anxiety pair explicitly flags the study as not yet fully peer-reviewed — framed as an emerging lead requiring a vet/behavioral consult, not a standalone anxiety treatment.
- Added one overview/ranking pair ("which supplements have the strongest science") so the assistant can answer a broad "what actually works" question with the full tier breakdown in one shot.
Related: [[PINECONE_PROTOCOL]], [[Joint Health Research]], [[Supplement Evidence by Benefit]]